Fundamental Research

We are investigating the cellular and molecular mechanisms by which microglia and other immune cells regulate central nervous system white matter health across the lifespan. We are identifying new roles for microglia in myelin development, homeostasis, and ageing.

Translational Research

We are identifying the roles of microglia and other immune cells in regulating myelin development or regeneration following injury, revealing therapeutic targets and strategies for conditions in which central nervous system white matter health is poor (e.g. perinatal brain injury/ cerebral palsy, multiple sclerosis, and normal ageing/ dementia). We actively collaborate with, and consult for, pharmaceutical industry to support drug development.

Approaches & Innovation

We use a comprehensive approach to our research, combining experimental modelling (in vitro, ex vivo, in vivo), transgenic and pharmacological manipulation, ‘omics (digital spatial profiling, RNA seq, sc-RNAseq, TRAPseq, proteomics), drug screening and nanoparticle delivery, and human neuropathological analysis and cell culture.

Recent news

If you currently menstruate or have ever menstruated and are 18+, @KateClancy is leading a study on your experiences getting at least 1 dose of a COVID vaccine:

Medicines and vaccines are constantly evaluated for safety to ensure benefits outweigh any potential risks. These reviews start early in medicine development, through to ongoing safety monitoring in the ‘real-world’. #whatsciencecando https://know.az/2Tow7PD

Did you know you can drop in for a #COVID19 vaccination at various sites across #Edinburgh (1st dose or 2nd dose more than 8 weeks after your 1st)?
Check out the details and just pop along - no appointments needed! https://www.nhslothian.scot/Coronavirus/Vaccine/Pages/Drop-in-Clinics.aspx

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