We are investigating the cellular and molecular mechanisms by which microglia and other immune cells regulate central nervous system white matter health across the lifespan. We are identifying new roles for microglia in myelin development, homeostasis, and ageing.
We are identifying the roles of microglia and other immune cells in regulating myelin development or regeneration following injury, revealing therapeutic targets and strategies for conditions in which central nervous system white matter health is poor (e.g. perinatal brain injury/ cerebral palsy, multiple sclerosis, and normal ageing/ dementia). We actively collaborate with, and consult for, pharmaceutical industry to support drug development.
We use a comprehensive approach to our research, combining experimental modelling (in vitro, ex vivo, in vivo), transgenic and pharmacological manipulation, ‘omics (digital spatial profiling, RNA seq, sc-RNAseq, TRAPseq, proteomics), drug screening and nanoparticle delivery, and human neuropathological analysis and cell culture.
Veronica accepts Chair and Professorship in Canada. Veronica has taken up the John David Eaton Chair in Multiple Sclerosis Research…
Irene chair session & presents at MS Frontiers. Irene chaired a session, and gave talks on her work on astrocytes…
Sarah wins presentation prize. Sarah Kent won the PhD student oral presentation prize at the Macrophage Symposium: A Cell for…
Lab presentations at Myelin GRC Niamh McNamara presented her new work on microglia regulation of myelin health as an invited…
Ayisha wins poster prize. Ayisha Mahmood won a poster prize at the Biochemical Society Drug Repurposing Conference, for her work…
Alana receives prestigious postdoctoral fellowship. Congratulations to Alana who has received the Walter-Benjamin fellowship from the German Research Foundation, to…
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