Harnessing the regenerative properties of inflammation for myelin health across the lifespan.

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Fundamental Research

We are investigating the cellular and molecular mechanisms by which microglia and other immune cells regulate central nervous system white matter health across the lifespan. We are identifying new roles for microglia in myelin development, homeostasis, and ageing.

Translational Research

We are identifying the roles of microglia and other immune cells in regulating myelin development or regeneration following injury, revealing therapeutic targets and strategies for conditions in which central nervous system white matter health is poor (e.g. perinatal brain injury/ cerebral palsy, multiple sclerosis, and normal ageing/ dementia). We actively collaborate with, and consult for, pharmaceutical industry to support drug development.

Approaches & Innovation

We use a comprehensive approach to our research, combining experimental modelling (in vitro, ex vivo, in vivo), transgenic and pharmacological manipulation, ‘omics (digital spatial profiling, RNA seq, sc-RNAseq, TRAPseq, proteomics), drug screening and nanoparticle delivery, and human neuropathological analysis and cell culture.

Recent news
Ayisha wins poster prize

Ayisha wins poster prize. Ayisha Mahmood won a poster prize at the Biochemical Society Drug Repurposing Conference, for her work…

We are hiring postdocs!

Are you interested in discovering the enigmatic functions of oligodendrocyte precursor cells in the formation and function of neural circuits, using zebrafish genetics, imaging, physiology & behaviour?

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Nearly 6% of children suffer from #COVID19 symptoms three months later, eight-country study finds, by @BillGraveland https://www.theglobeandmail.com/canada/article-nearly-6-of-children-suffer-from-long-term-covid-19-symptoms-eight/?utm_medium=Referrer:+Social+Network+/+Media&utm_campaign=Shared+Web+Article+Links via @globeandmail #LongCOVID

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